Fig. 3: Gene induction during pregnancy and lactation is controlled by promoter and enhancer elements. | Experimental & Molecular Medicine

Fig. 3: Gene induction during pregnancy and lactation is controlled by promoter and enhancer elements.

From: The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy

Fig. 3

a Scatter plot of normalized exon reads vs. Pol II ChIP-seq reads of expressed genes in the wt/Wap-Tbrg4 mammary tissue on L10. Red dots, SE-associated genes. b Expression levels of exons and introns in wt/Wap-Tbrg4 of mammary glands on L10 are shown, as determined by total RNA-seq. c Wap, Tbrg4 and Tbrg4-3′UTR mRNA levels from WT and Tb-Wap 3′UTR mutant mice were measured by qRT-PCR on L1 and normalized to the Gapdh level. Results are shown as the means ± SEM of independent biological replicates (WT and mutants, n = 3). Multiple t-tests were used to evaluate the significance of differences between the WT and mutants. ns not significant.

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