Fig. 1: An overview of cotranscriptional m6A mRNA modification.
From: Diverse molecular functions of m6A mRNA modification in cancer
Introduction of m6A modification is currently suggested to occur cotranscriptionally in the nucleus. Individually transcribing mRNAs illustrate the different modes of cotranscriptional m6A modification, including different compositions of associated DNA- and RNA-binding proteins with distinct methylation sites. The thick line represents the coding sequence, and the thin line represents the UTR. The dashed box indicates the heat shock condition.
