Table 1 Cellular effects of m6A mRNA modification in cancer.
From: Diverse molecular functions of m6A mRNA modification in cancer
Positive regulation of m6A in cancer | Negative regulation of m6A in cancer | |||||
|---|---|---|---|---|---|---|
Molecular function | Target | Reference | Molecular function | Target | Reference | |
Lung cancer | Translation | A subset of mRNAs | mRNA level change | A subset of mRNAs | ||
EGFR, TAZ, MAPKAPK2, DNMT3A mRNA | ||||||
Protein level change | BAX, BCL-2 | mRNA stabilization | MZF1 mRNA | |||
Acute myeloid leukemia | Translation | A subset of mRNAs | mRNA stabilization | ASB2, RARA mRNA | ||
MYC, BCL2, PTEN mRNA | ||||||
Translation | MYB, MYC mRNA | mRNA decay | A subset of mRNAs | |||
mRNA stabilization | ||||||
Hepatocellular carcinoma | mRNA level change | SOCS2 mRNA | NR | NR | ||
mRNA decay | EGFR mRNA | |||||
mRNA level change | SON, SREBBP mRNA | |||||
Breast cancer | mRNA level change | HBXIP mRNA | mRNA level change | NANOG, KFL4 mRNA | ||
Gastric cancer | mRNA stabilization | SEC62 mRNA | Unknown | Unknown | ||
HDGF mRNA | ||||||
Bladder cancer | mRNA level change | AFF4, MYC mRNA | NR | NR | ||
Protein level change | AFF4, MYC, IKBKB, RELA | |||||
Translation | ITGA6 mRNA | |||||
Glioblastoma | mRNA stabilization | SOX2 mRNA | mRNA level change | Nascent FOXM1 transcript | ||
mRNA level change | A subset of mRNAs | |||||
Colorectal cancer | mRNA stabilization | SOX2 mRNA | NR | NR | ||
Renal cell carcinoma | NR | NR | Unknown | Unknown | ||
Endometerial Cancer | NR | NR | Translation | PHLPP2 mRNA | ||
mRNA decay | PRR5, PRR5L, mTOR mRNA | |||||
Cervical cancer | NR | NR | Unknown | Unknown | ||
Pancreatic cancer | NR | NR | Protein level change | YAP | ||
