Fig. 6: The deacetylated HINT1 mutant (HINT1 2KR) suppresses tumorigenesis in an in vivo xenograft mouse model. | Experimental & Molecular Medicine

Fig. 6: The deacetylated HINT1 mutant (HINT1 2KR) suppresses tumorigenesis in an in vivo xenograft mouse model.

From: Deacetylation by SIRT1 promotes the tumor-suppressive activity of HINT1 by enhancing its binding capacity for β-catenin or MITF in colon cancer and melanoma cells

Fig. 6

Nude mice (five mice/group) were injected with 1 × 107 DLD1 cells stably transfected with mock control or with the Flag-HINT1 WT or 2KR construct. The xenograft tumors were measured at the indicated times and dissected at the endpoint. a Representative images of mice are shown. Scale bar: 1 cm. b Quantification of the average volume of tumors as indicated times is shown. The data show the mean ± SEM versus negative control pCDH-VEC. **P < 0.01. c Protein levels of cyclin D1 and c-Myc were determined by western blot assay in tumors derived from three nude mice from each group.

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