Fig. 5: Model of the modulation of cellular α-syn uptake and degradation by Toll-like receptor 2. | Experimental & Molecular Medicine

Fig. 5: Model of the modulation of cellular α-syn uptake and degradation by Toll-like receptor 2.

From: Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells

Fig. 5

Innate immune receptor stimulation increased the uptake of α-syn fibrils in neurons, astrocytes, and microglia. This stimulation delayed the degradation of internalized α-syn in neurons and astrocytes but not in microglia, thereby accelerating α-syn and p62 accumulation. In microglia, internalized α-syn was rapidly degraded in regardless whether the cells were stimulated. Innate immune receptor expression upregulation in α-syn-tg mice promoted the transformation of microglia to an ameboid, reactive morphology.

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