Fig. 2: Morphological changes in the retinas of Pde6b knockout rats after the transplantation of hiPSC-derived retinal cells into the subretinal space. | Experimental & Molecular Medicine

Fig. 2: Morphological changes in the retinas of Pde6b knockout rats after the transplantation of hiPSC-derived retinal cells into the subretinal space.

From: Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats

Fig. 2

a Schematic diagram of subretinal injection of hiPSC-derived retinal cells. b Fundus images of the transplantation area taken between 2 weeks and 10 months after the injection of cells. The yellow arrowheads indicate the transplantation area. c Optical coherence tomography (OCT) images taken between 2 weeks and 10 months after transplantation. The yellow arrowheads indicate the transplantation area. The white line on each fundus image indicates the location of the OCT scan. d The results of the PCR analysis of mitochondrial DNA confirmed the presence of hiPSC-derived retinal cells at the injection site 2 weeks (DNA template concentration of 500 ng/μl) and 4 months (DNA template concentration of 5000 ng/μl) after transplantation. M1: 1 kb ladder. Left lanes 1, 2, 3: 2 weeks; right lane 1: 4 months. hiPSC-R hiPSC-derived retinal cell transplantation group. Scale bars, 100 μm.

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