Fig. 4: Phosphorylation level of SOX9 and its interaction with p-ERK1/2 in GMCs following sublytic C5b-9 exposure and in renal tissues of Thy-1N mice. | Experimental & Molecular Medicine

Fig. 4: Phosphorylation level of SOX9 and its interaction with p-ERK1/2 in GMCs following sublytic C5b-9 exposure and in renal tissues of Thy-1N mice.

From: Sublytic C5b-9 induces glomerular mesangial cell proliferation via ERK1/2-dependent SOX9 phosphorylation and acetylation by enhancing Cyclin D1 in rat Thy-1 nephritis

Fig. 4

a The protein levels of t-ERK1/2, p-SOX9, and SOX9 and the interaction between SOX9 and p-ERK1/2 in sublytic C5b-9-treated rat GMCs at different time points. b The protein levels of t-ERK1/2, p-SOX9, and SOX9 and the interaction between SOX9 and p-ERK1/2 in GMCs at 3 h with various treatments. c The protein levels of t-ERK1/2, p-SOX9, and SOX9 and the interaction between SOX9 and p-ERK1/2 in renal tissue of Thy-1N rats at different time points. d The protein levels of t-ERK1/2, p-SOX9, and SOX9 and the interaction between SOX9 and p-ERK1/2 at 3 h in the renal tissues of Thy-1N and NRS control rats. *p < 0.05, **p < 0.01 versus the 0 h, MEM, Thy-1 Ab, Thy-1 Ab + HIS, Thy-1 Ab + C6DS, or NRS group. Data were represented as the means ± SD (n = 3 in vitro, n = 5 in vivo at each time point or in each group).

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