Fig. 4: Different physiological outcomes mediated by caspase-2-dependent p53 stabilization. | Experimental & Molecular Medicine

Fig. 4: Different physiological outcomes mediated by caspase-2-dependent p53 stabilization.

From: The p53-caspase-2 axis in the cell cycle and DNA damage response

Fig. 4

A proposed scheme showing that PIDDosome-mediated caspase-2 activation, MDM2 cleavage and p53 stabilization serves as a checkpoint under conditions of sustained DNA damage to induce cell cycle arrest or apoptosis. The figure was created with BioRender.com.

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