Table 2 Representative studies on self-illuminating PDTs.
From: Tailoring photosensitive ROS for advanced photodynamic therapy
Energy source (component) | Transducer or carrier | Photosensitizer (type) | Targeting strategy (target) | Ref. |
|---|---|---|---|---|
CL (luminol/H2O2) | Oligo (p-phenylene vinylene) | Oligo (p-phenylene vinylene) (Chemical) | Passive targeting (xenograft mice of HeLa; Fungus, C. albicans) | |
CL (luminol/H2O2) | Polymer dot | m-THPC (Foscan) (Chemical) | Active targeting (C6 and MCF-7 cells) | |
CL (CPPO/H2O2) | Pluronic F-127 | TPE-BT-DC (Chemical) | Passive targeting (4T1 cells and xenograft mouse) | |
CL (luminol/H2O2) | PEG polymer | Chlorine e6 (Chemical) | Passive targeting (macrophage, some cancer cells, and inflammation mouse) | |
CL (luminol/H2O2) | Carbon dot | Chlorine e6 (Chemical) | Passive targeting (SMMC-7721 cells and xenograft mouse) | |
BL (Fluc/luciferin) | Gene transfection agent | Rose bengal (Chemical) | Passive targeting (NIH 3T3 cells) | |
BL (Rluc variant/CTZ) | Quantum dot | m-THPC (Foscan) (Chemical) | Passive targeting (A549 cells and xenograft mice) | |
BL (Rluc variant/CTZ) | Quantum dot | Chlorine e6 (Chemical) | Passive targeting (B16F10, CT26, or LLC cells and their xenograft mice) | |
BL (Fluc/luciferin) | PLGA nanoparticle | Rose bengal (Chemical) | Passive targeting (MCF-7 and HeLa cells) | |
BL (Gluc variant/CTZ) | Mini-ferritin | Protoporphyrin IX (Chemical) | Passive targeting (SK-BR-3 and MDA-MB-231 cells) | |
BL (Nluc) | Gene transfection agent | miniSOG (Protein) | Passive targeting (SK-BR-3 cells) | |
BL (Rluc variant/CTZ) | None | KillerRed, miniSOG (Protein) | Active targeting (Six BC cells, patient primary cells, and BC-xenograft mouse) |
