Fig. 3: Structural comparison of coronavirus spike proteins.
a Long-axis trimer, closed conformation view of the cryo-EM spike protein structure from the pangolin coronavirus (PDB ID: 7CN8, left panel), human SARS-CoV-2 (PDB ID: 6ZB5, middle panel), and bat RaTG13 coronavirus (PDB ID: 7CN4, right panel). Models are rainbow colored from the N-terminus (blue) to the C-terminus (red). b Left panel depicts human SARS-CoV-2 (colored by chain: purple, yellow, and green) and the ACE2 complex (colored red) in bound confirmation (PDB ID: 6ACG). The right panel shows a magnified region encompassing 8 amino acids (positions shown in blue, green, and red) detected as targets of positive selection in the previous studies27,47,50. The positions in blue were identified as positively selected in one of the three cited studies, while the positions depicted in red (493 and 494) were identified in two studies. The green position 483 of the S protein was identified as positively selected in all three studies. For a, b all models were visualized by SWISS-MODEL66.
