Fig. 3: Bone marrow adiposity is increased in Stat5 cKO mice. | Experimental & Molecular Medicine

Fig. 3: Bone marrow adiposity is increased in Stat5 cKO mice.

From: Alternative regulatory mechanism for the maintenance of bone homeostasis via STAT5-mediated regulation of the differentiation of BMSCs into adipocytes

Fig. 3

a, b Femurs isolated from Stat5 cKO mice (n = 4) and their wild-type littermates (n = 3) were subjected to osmium/tetroxide staining. a Representative images of osmium/tetroxide-stained femurs isolated from Stat5 cKO mice and their wild-type littermates. b Quantification of osmium tetroxide-stained bone marrow adipose tissue based on micro-CT analysis. *P < 0.05 vs. control. Statistical analyses were performed via Student’s t test. c, d Tibias harvested from Stat5 cKO mice and their wild-type littermates were subjected to hematoxylin & eosin staining (n = 10 per group). c Representative images of hematoxylin & eosin-stained tibias harvested from Stat5 cKO mice and their wild-type littermates. d Quantification of bone marrow adipose tissue based on hematoxylin & eosin staining. ***P < 0.001 vs. control. Statistical analyses were performed via Student’s t test. Bars: (a) 500 µm; (c) 100 µm.

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