Fig. 2: Organoids and organoid-derived models.
From: Organoids as host models for infection biology – a review of methods
Organoids are derived from tissue-specific adult stem cells (ASCs) or pluripotent stem cells (iPSCs). The cells differentiate into different cell types, which self-organize into domains and thus resemble the native tissue architecture, yielding reductionist models of organs. ASCs can easily be maintained in culture for long-term expansion, seeded in 2D monolayers, and seeded in tissue engineering models, including scaffolds, providing more structural complexity to resemble the physiological microenvironment for cell growth and distribution.
