Fig. 2: Radioresistance of cells induced by UCHL1-HIF-1 pathway-dependent reprogramming of the carbohydrate metabolic pathway. | Experimental & Molecular Medicine

Fig. 2: Radioresistance of cells induced by UCHL1-HIF-1 pathway-dependent reprogramming of the carbohydrate metabolic pathway.

From: Tumor microenvironment and radioresistance

Fig. 2

HIF-1 mediates reprogramming of the glucose metabolic pathway from mitochondrial oxidative phosphorylation to glycolysis. UCHL1 causes radioresistance by inducing HIF-1-mediated reprogramming and a resulting increase in the intracellular level of GSH in a PPP-dependent manner.

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