Fig. 1: ACOT12 in acetyl-CoA metabolism is involved in NAFLD.
From: Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue
a Transcription level of 35 enzymes related to acetyl-CoA metabolism in the GSE48452 dataset. b Transcription level of ACOT12 in the GSE48452 dataset. c The Kaplan–Meier plot of HCC patient survival with no alcohol consumption in the high-ACOT12 and low-ACOT12 groups. d Representative image of immunohistochemical staining of ACOT12 from normal (n = 14) and steatotic patient (n = 61) liver biopsies. e Hepatic triglyceride (TG), total cholesterol (TC), free fatty acid (FFA), and acetyl-CoA levels in NCD, HFD, HFHCD, and ob/ob mice (n = 3 mice per group). The diet chow strategy is presented as a bar graph. f Representative immunohistochemical staining of ACOT12 from normal chow diet (NCD)-, high-fat diet (HFD)-, and high-fat high-cholesterol diet (HFHCD)-fed wild-type mice and HFD ob/ob mouse livers. Scale bars, 100 μm. g Transcription level of Acot12 in NCD, HFD, HFHCD, and ob/ob mice (n = 3 per group). All data are presented as the mean ± SEM. Statistical differences among three or more groups were performed using one-way ANOVA, followed by Dunnett’s multiple comparison test (f, g) or Fisher’s LSD post hoc test (b). n.s = nonsignificant; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.
