Fig. 5: Investigation of intratumoral heterogeneity and tumor evolution.
From: Gastrointestinal cancer organoids—applications in basic and translational cancer research
a PDOs provide an excellent platform to study the functional relevance of intratumoral heterogeneity by generating organoids from different regions of the tumor. b Cancer organoids have also been used to study tumor evolution by comparing PDOs from primary and metastatic sites of a patient.
