Fig. 2: Transcriptome analysis of MI using total RNA sequencing analysis. | Experimental & Molecular Medicine

Fig. 2: Transcriptome analysis of MI using total RNA sequencing analysis.

From: MicroRNA-26a/b-5p promotes myocardial infarction-induced cell death by downregulating cytochrome c oxidase 5a

Fig. 2

a Volcano plot and b hierarchical clustering heatmap of differentially expressed genes in the hearts of control and MI rats. c Significantly expressed genes and d fold enrichment of genes determined by Gene Ontology analysis with DAVID. e GSEA of up/downregulated genes revealed molecular pathways related to cell activation, cell activation involved in the immune response, negative regulation of cell population proliferation, and regulation of the apoptotic signaling pathway. The green dots in the volcano plot indicate genes with decreased expression, and the red dots indicate genes with increased expression in MI compared with CON. Significant differences between groups were determined via ANOVA, with p values indicated as *p < 0.05 and **p < 0.01. CON control rat group, MI myocardial infarction rat group. n = 3 rats per group.

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