Fig. 2: Comparison of EC subpopulations in ascending aortas from ND and HFD mice. | Experimental & Molecular Medicine

Fig. 2: Comparison of EC subpopulations in ascending aortas from ND and HFD mice.

From: Single-cell transcriptome analysis reveals cellular heterogeneity in the ascending aortas of normal and high-fat diet-fed mice

Fig. 2

a t-SNE plot of the EC subpopulations (EC_1, EC_2, and EC_3) from the ND (336 cells) and HFD (521 cells) groups. b Percentages of the EC subpopulations in the ND (EC_1, 49%; EC_2, 28%; and EC_3, 23%) and HFD (EC_1, 60%; EC_2, 23%; and EC_3, 17%) groups. c Heatmap of the top 10 marker genes per subpopulation. d Violin plots of signature genes confirming the subpopulation identities. e–g Top 10 pathways associated with the EC_1 (e), EC_2 (f), and EC_3 (g) clusters. h Feature plots of the expression of selected marker genes for the EC subpopulations from the ND and HFD groups. i Violin plots of the expression of selected marker genes for the EC subpopulations from the ND and HFD groups. j Expression of cluster-specific and contractile genes for EC subpopulations as visualized by dot plot.

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