Fig. 3: Comparison of SMC subpopulations in ascending aortas from ND and HFD mice. | Experimental & Molecular Medicine

Fig. 3: Comparison of SMC subpopulations in ascending aortas from ND and HFD mice.

From: Single-cell transcriptome analysis reveals cellular heterogeneity in the ascending aortas of normal and high-fat diet-fed mice

Fig. 3

a, t-SNE plots of the SMC subpopulations (SMC_1, SMC_2, SMC_3, SMC_4, and SMC_5) from the ND (2,601 cells) and HFD (2,370 cells) groups. b, Percentages of the SMC subpopulations from the ND (SMC_1, 43%; SMC_2, 37%; SMC_3, 14%; SMC_4, 4%; and SMC_5, 1%) and HFD (SMC_1, 64%; SMC_2, 23%; SMC_3, 12%; SMC_4, 0.8%; and SMC_5, 0.2%) groups. c, Heatmap of the top 20 marker genes per subpopulation. d–f, Top 10 pathways associated with the SMC_1 (d), SMC_2 (e), and SMC_3 (f) clusters. g, Feature plots of the expression of selected marker genes for the SMC subpopulations from the ND and HFD groups. h, Violin plots of the expression of selected marker genes for the SMC subpopulations from the ND and HFD groups. i, Expression of extracellular matrix (ECM) degradation-associated genes for SMC subpopulations as shown by violin plots.

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