Fig. 5: Ligand–receptor interaction analyses to assess intracellular communication in ascending aortas from ND and HFD mice. | Experimental & Molecular Medicine

Fig. 5: Ligand–receptor interaction analyses to assess intracellular communication in ascending aortas from ND and HFD mice.

From: Single-cell transcriptome analysis reveals cellular heterogeneity in the ascending aortas of normal and high-fat diet-fed mice

Fig. 5

a An inferred intercellular communication network for CXCL signaling among endothelial cells, smooth muscle cells, and monocytes/macrophages is shown in the circle plot (the number of cells in each cluster is proportional to the circle size; the line thickness represents the strength of signaling). b The importance of each cluster based on the four network centrality measures of CXCL signaling is shown in the heatmap. c Relative contribution of each ligand-receptor pair to the overall communication network of the CXCL signaling pathway. d An inferred intercellular communication network for CCL signaling among endothelial cells, smooth muscle cells, and monocytes/macrophages is shown in the circle plot. e The importance of each cluster based on the four network centrality measures of CCL signaling is shown in the heatmap. f Relative contribution of each ligand-receptor pair to the overall communication network of the CCL signaling pathway. g, h Outgoing communication patterns of secreting cells (g) and incoming communication patterns of target cells (h) are shown in the alluvial plot.

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