Fig. 6: hCSC-primed MHY-1685 reduces adverse cardiac remodeling and protects the myocardium against ischemic injury. | Experimental & Molecular Medicine

Fig. 6: hCSC-primed MHY-1685 reduces adverse cardiac remodeling and protects the myocardium against ischemic injury.

From: Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair

Fig. 6

a Representative images of Masson’s trichrome staining using heart tissues harvested 4 weeks after intervention. Scale bar: 2000 µm. b, c Quantification summary of the percentage of fibrosis and viable myocardium. n = 4–7. (*p < 0.05 vs. control, #p < 0.05 vs. senescent hCSC). d Representative images of denatured collagen in the infarct zone and their quantification summary. CHP (green), DiI-labeled hCSCs (red), DAPI (blue). n = 3. (*p < 0.05 vs. control, #p < 0.05 vs. senescent hCSC). Scale bar: 100 µm. e Representative images of cardiomyocytes in the infarct zone and their quantification summary. cTnT (green), DiI-labeled hCSCs (red), DAPI (blue). n = 3. (*p < 0.05 vs. control, #p < 0.05 vs. senescent hCSC). Scale bar: 100 µm. Data are shown as the mean ± S.E.M.

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