Fig. 5: Prmt1 inhibition in VSMCs elevates cellular stress triggered by mechanical stretch. | Experimental & Molecular Medicine

Fig. 5: Prmt1 inhibition in VSMCs elevates cellular stress triggered by mechanical stretch.

From: Inducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection

Fig. 5

a Immunoblot analysis of γH2AX in the f/f and smKO aortas. b Quantification of the γH2AX intensity relative to β-actin. (n = 5). Data represent the mean ± SD. *P < 0.05, Student’s t-test. c Immunostaining for γH2AX in A7R5 cells treated with Fura followed by 10% cyclic stretch for 2 h. Scale bar: 50 μm. d Quantification of γH2AX-positive cells (red) (n = 89–114). Data represent the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, Student’s t-test.

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