Table 2 Level and activity of c-proteasomes in human plasma.

First author	Year	Disease	Disease in detail	N	Plasma proteasome concentration (ng/mL)	Chymotrypsin-like activity	Ref
Lavabre-Bertrand^a	2001	Healthy		73	2356	N/A	⁴²
		Hemopoietic malignancies	Solid tumor	20	7589
			Myeloproliferative disorder	37	4099
			Myelodysplastic syndromes	19	2922
Stoebner^b	2005	Healthy		14	1957	N/A	⁴⁴
		Metastatic malignant melanoma	Stage I/II	13	2515
			Stage III	6	3725
			Stage IV	10	8554
			Severe psoriasis	13	2981
			Chronic idiopathic urticaria	6	3190
Henry^b	2009	Healthy		40	2302	N/A	⁴⁵
		Liver cirrhosis	with hepatocellular carcinoma (HCC)	50	3737
		Liver cirrhosis	without HCC	33	1808
Henry^b	2013	Metastatic melanoma	Stage I/II	53	184	N/A	⁴⁶
			Stage III	41	228
			Stage IV	27	499
Ma^b	2008	Healthy		40	N/A	0.80 pmol/s/mL	⁴⁷
Ma^b	2008	Chronic lymphocytic leukemia		225	N/A	1.84 pmol/s/mL	⁴⁷
Ma^b	2009	Healthy		97	N/A	0.8 pmol/s/mL	⁴⁸
		Acute myeloid leukemia		174	N/A	2.0 pmol/s/mL
		Myelodysplastic syndrome		52	N/A	1.4 pmol/s/mL
Majetschak^b	2010	Healthy		40	195	N/A	⁵⁴
		Burn	Day 0	50	673
		Burn	Day 30	40	116.5
Heubner^b	2011	Healthy		55	290	N/A	⁵⁵
		Epithelial ovarian cancer	Patient	120	595
		Epithelial ovarian cancer	Patient, after therapy	68	457.5
Hoffmann^b	2011	Healthy		50	305	N/A	⁵⁶
Hoffmann^b	2011	Nonmetastasized breast cancer		224	397.5	N/A	⁵⁶
Fukasawa^b	2015	Healthy		76	1,340	N/A	⁵⁷
Fukasawa^b	2015	Hemodialysis patient		76	1.381	N/A	⁵⁷
Manasanch^b	2017	Multiple myeloma	Patient	45	N/A	0.83 pmol/s/ml	⁵⁸
Manasanch^b	2017	Multiple myeloma	After carfilzomib treatment		N/A	0.23 pmol/s/ml	⁵⁸
Oldziej^b	2014	Healthy		30	2010	1.02 U/mg	⁵⁹
Oldziej^b	2014	Multiple myeloma		64	4380	1.32 U/mg	⁵⁹

Quick links

Search