Fig. 1: AC008 is upregulated in human osteoarthritic cartilage. | Experimental & Molecular Medicine

Fig. 1: AC008 is upregulated in human osteoarthritic cartilage.

From: m6A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p‒AQP1/ANKH axis

Fig. 1

a A cluster heat map showing the differentially expressed lncRNAs, mRNAs, and miRNAs between normal and osteoarthritic cartilage (n = 3). b The expression level of AC008 in normal and osteoarthritic cartilage was evaluated by qRT–PCR (n = 39). c Safranin-O staining was performed to assess ECM degradation in normal and osteoarthritic cartilage samples (scale bar = 500 μm). d IHC staining was conducted to evaluate the expression levels of COL2A1 and MMP13 in normal and osteoarthritic cartilage samples (scale bar = 200 μm). The quantification of cells positive for COL2A1 and MMP13 staining is shown in the right panel. OA osteoarthritis. The data are presented as the means ± SDs. Statistical differences were determined by unpaired two-tailed Student’s t test (b, d). **P < 0.01; ***P < 0.001.

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