Fig. 3: NLRC4 knockdown reduced accumulation of glial cells, neurological function damage and decreased brain edema after ICH. | Experimental & Molecular Medicine

Fig. 3: NLRC4 knockdown reduced accumulation of glial cells, neurological function damage and decreased brain edema after ICH.

From: The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats

Fig. 3

a Modified Neurological Severity Scores (mNSS) for neurological function, b Brain edema in ipsilateral brain and contralateral brain for brain water content, e HE staining for the morphology (×400), f Nissl staining for the morphology (×400) and c Nissl staining for the number of nissl bodies, d Evans blue Dye extravasation and g autofluorescence (×400) for the integrity of blood brain barrier, h IF of Iba-1 staining for microglia. i IF of GFAP staining for astrocytes. Quantification of microglial accumulation (j) and astrogliosis (k) in the Sham, ICH, ICH + NC, and ICH + NLRC4 siRNA groups at 72 h after ICH. The data represent the means ± SEM. (six rats for each group). *P < 0.05, compared with ICH.

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