Fig. 6: LRRK2 inhibitor extenuated NLRC4 inflammasome activation after ICH. | Experimental & Molecular Medicine

Fig. 6: LRRK2 inhibitor extenuated NLRC4 inflammasome activation after ICH.

From: The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats

Fig. 6

a–g Western blot assay to detect LRRK2, pLRRK2, NLRC4, pNLRC4, pro- IL-1β, IL-1β, Pro- caspase-1, caspase-1, Pro-IL-18, and IL-18 (h and i) ELISA for IL-18 and IL-1β (j) Co-Immunoprecipitation assay for NLRC4 and LRRK2, in peri-hematoma area in sham, ICH, ICH + GNE7915, and ICH + Vehicle groups at 72 h after ICH (six rats for each group). *P < 0.05, compared with ICH.

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