Fig. 1: Hepatic lipid metabolism in fatty liver. | Experimental & Molecular Medicine

Fig. 1: Hepatic lipid metabolism in fatty liver.

From: Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease

Fig. 1

Circulating FAs are imported via FATPs, including CD36, FATP2, and FATP5. ACSL converts the FAs taken up by cells to acyl-CoA, which is further reesterified to produce glycerolipids, mainly in the ER. In addition, FAs can be synthesized via DNL using acetyl-CoA. These intracellular FAs can be consumed to generate VLDL by forming a complex with ApoB100 via MTP. Furthermore, FAs are cleaved to generate acetyl-CoA through FA oxidation in the mitochondria to produce ATP and ketone bodies. An imbalance between lipid disposal and storage promotes fatty liver disease.

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