Table 2 Multiple regression analysis on cognitively normal individuals.

From: Application of QPLEX^TM biomarkers in cognitively normal individuals across a broad age range and diverse regions with cerebral amyloid deposition

QPLEX^TM markers
Dependent Y						Cerebral amyloid deposition (SUVR)
Sample size						215
Coefficient of determination R²						0.1329
R²-adjusted						0.1163
Multiple correlation coefficient						0.3645
Residual standard deviation						0.2210
Ind. variables	Coefficient	Std. Error	t	P	r_partial	r_semipartial	VIF
(Constant)	1.1778
Aβ1–40	0.0009446	0.0003278	2.881	0.0044	0.1950	0.1851	1.131
LGALS3BP	−0.00002973	0.000008228	−3.613	0.0004	−0.2419	0.2322	1.211
ACE	−0.0004304	0.0001824	−2.359	0.0192	−0.1607	0.1516	1.465
POSTN	0.006219	0.001873	3.320	0.0011	0.2233	0.2134	1.587
QPLEX^TM markers + Sex + Age
Dependent Y						Cerebral amyloid deposition (SUVR)
Sample size						215
Coefficient of determination R²						0.2613
R²-adjusted						0.2400
Multiple correlation coefficient						0.5112
Residual standard deviation						0.2049
Ind. variables	Coefficient	Std. Error	t	P	r_partial	r_semipartial	VIF
(Constant)	0.9098
Aβ1–40	0.0006936	0.0003076	2.255	0.0252	0.1545	0.1344	1.158
LGALS3BP	−0.00002887	0.000007703	−3.747	0.0002	−0.2515	0.2233	1.234
ACE	−0.0003556	0.0001698	−2.094	0.0375	−0.1437	0.1248	1.476
POSTN	0.006376	0.001738	3.669	0.0003	0.2465	0.2186	1.588
Sex	−0.02188	0.02842	−0.770	0.4421	−0.0533	0.0459	1.024
Age	0.005013	0.0008386	5.977	<0.0001	0.3829	0.3562	1.026
QPLEX^TM markers + Sex + Age + ApoE genotype
Dependent Y						Cerebral amyloid deposition (SUVR)
Sample size						215
Coefficient of determination R²						0.2810
R²-adjusted						0.2567
Multiple correlation coefficient						0.5301
Residual standard deviation						0.2027
Ind. variables	Coefficient	Std. Error	t	P	r_partial	r_semipartial	VIF
(Constant)	0.8908
Aβ1–40	0.0006864	0.0003043	2.256	0.0251	0.1549	0.1329	1.158
LGALS3BP	−0.00002854	0.000007619	−3.746	0.0002	−0.2519	0.2207	1.234
ACE	−0.0003705	0.0001680	−2.205	0.0286	−0.1515	0.1299	1.478
POSTN	0.006314	0.001719	3.674	0.0003	0.2474	0.2165	1.589
Sex	−0.01911	0.02813	−0.679	0.4977	−0.0472	0.0400	1.025
Age	0.005049	0.0008295	6.087	<0.0001	0.3896	0.3587	1.027
ApoE	0.07754	0.03259	2.379	0.0183	0.1632	0.1402	1.006

SUVR standardized uptake value ratio, Ind. independent, VIF variance inflation factor, Aβ1–40 beta-amyloid 1–40, LGALS3BP galectin-3 binding protein, ACE angiotensin-converting enzyme, POSTN periostin, ApoE apolipoprotein E.

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Table 2 Multiple regression analysis on cognitively normal individuals.

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