Fig. 1: Glucose tolerance and insulin secretion in the Senp2-βKO mice.
From: SENP2 regulates mitochondrial function and insulin secretion in pancreatic β cells
a Pancreatic islets were isolated from the control (CTL) or Senp2-βKO (βKO) mice, and then, SENP2 expression was detected by western blot analysis. b Pancreatic islets were subjected to immunofluorescence staining using antibodies against SENP2 and insulin; scale bar: 100 μm. c–e The control and Senp2-βKO mice were fed a control chow diet (CD). c Body weights. Serum glucose (d) and insulin levels (e) were measured at the indicated time points after glucose infusion (2 g/kg body weight). Data are presented as the mean ± SEM, n = 7 (CTL), 9 (βKO) (body weight), 5 (CTL), 6 (βKO) (GTT), and 6 (CTL), 7 (βKO) (insulin levels). *P < 0.05, t-test. f–h The control and Senp2-βKO mice were fed a high-fat diet (HFD). f Body weights. Serum glucose (g) and insulin levels (h) after glucose infusion (1 g/kg body weight). Data are presented as the mean ± SEM, n = 9 (CTL), 7 (βKO) (body weight, GTT), and 6 (serum insulin). *P < 0.05, t-test. All data are presented as the mean ± SEM.
