Fig. 2: Alterations in gut microbiota composition in CTRP9-KO mice with atherosclerosis.

The V3-V4 region of bacterial 16 S rRNA was sequenced in fecal samples from 6-week-old CTRP9-KO (n = 6) and WT (n = 6) mice. a Alpha diversity analysis based on Shannon’s index (proxy for diversity) and Chao1 (proxy for richness) at the phylum level. b Beta-diversity analysis based on Bray–Curtis (qualitative measure) and Jaccard distances (quantitative measure). c Relative abundance of the total gut microbiota at the phylum level in CTRP9-KO and WT mice. d Percentage of bacterial taxa discriminating the gut microbiota in CTRP9-KO and WT mice.