Fig. 7: CircKIF18A ameliorates IVDD in a needle puncture rat model. | Experimental & Molecular Medicine

Fig. 7: CircKIF18A ameliorates IVDD in a needle puncture rat model.

From: Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration

Fig. 7

a S&O staining revealed the effects of circKIF18A overexpression adenovirus treatment on IVDD in vivo (n = 9; scale bar: 1000 μm). b Alcian blue staining revealed the effects of circKIF18A overexpression adenovirus treatment on IVDD in rats (n = 9; scale bar: 1000 μm). c The effects of circKIF18A overexpression adenovirus treatment on disc height in rats were determined using X-ray imaging (n = 9). d The statistical graph of histological scores in different groups according to S&O staining (n = 9; *P < 0.05; **P < 0.01). e The statistical graph of the disc height index in different groups according to X-ray imaging (n = 9; *P < 0.05; **P < 0.01). f The effects of circKIF18A on ECM metabolism in rat IVDs (n = 5; scale bar: 50 μm). g CircKIF18A overexpression adenovirus treatment increased the p53 level in NPs (n = 5; scale bar: 50 μm). h Representative images of immunofluorescence staining for p21 in punctured NPs (n = 5; scale bar: 50 μm). i Representative images of immunofluorescence staining for p16 in punctured NPs (n = 5; scale bar: 50 μm). All data are presented as the mean ± SD values.

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