Fig. 5: HSP70 suppressed compression-induced mitochondrial fission in NP cells. | Experimental & Molecular Medicine

Fig. 5: HSP70 suppressed compression-induced mitochondrial fission in NP cells.

From: HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3

Fig. 5

a The effects of TRC on the expression of DRP1, MFF, Fis1, Mfn1, Mfn2, and OPA1 (N = 3). b Representative fluorescence photomicrograph of TOM20 examined by immunofluorescence staining (N = 3, original magnification: ×1000). c The morphological ultrastructural appearance of mitochondria observed by TEM (N = 3). d The effects of VER on the expression of DRP1, MFF, Fis1, Mfn1, Mfn2, and OPA1 in NP cells treated with TRC (N = 3). e Representative fluorescence photomicrograph of TOM20 examined by immunofluorescence staining of NP cells treated with TRC and VER (N = 3, original magnification: ×1000). f Representative fluorescence photomicrograph of TOM20 examined by immunofluorescence staining of NP cells treated with TRC and HSP70-specific siRNAs (N = 3, original magnification: ×1000).

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