Fig. 8: SIRT3 mediated the inhibitory effects of HSP70 on the mitochondrial apoptotic pathway. | Experimental & Molecular Medicine

Fig. 8: SIRT3 mediated the inhibitory effects of HSP70 on the mitochondrial apoptotic pathway.

From: HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3

Fig. 8

a The MMP and the production of mtROS and cellular ROS in NP cells measured by flow cytometry. b The effects of 3-TYP on ATP production in NP cells treated with TRC. c, d The effects of 3-TYP on apoptosis of NP cells measured by flow cytometry using Annexin V-FITC/PI staining. e Typical fluorescence photomicrograph of TUNEL staining in NP cells (scale bar: 50 μm). f The effects of 3-TYP on the expression of cleaved caspase 3, cleaved caspase 9, Bax, and Bcl-2 in NP cells treated with TRC. (N = 3, *P < 0.05, **P < 0.01; ***P < 0.001, NS not significant).

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