Fig. 4: RTN3-null mouse kidneys showing mitochondrial structure damage. | Experimental & Molecular Medicine

Fig. 4: RTN3-null mouse kidneys showing mitochondrial structure damage.

From: Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells

Fig. 4

a TEM analysis showing the mitochondrial structures in renal tubular cells of WT and RTN3-null mice. b Real-time PCR results showing the mRNA levels of MFN2, FIS1, OPA1, and RTN3 in WT and RTN3-null mouse kidneys. Western blot analysis showing the protein levels of MFN2, FIS1, OPA1, RTN3 and β-actin in c, d WT and RTN3-null mouse kidneys and e, f WT and RTN3-null mouse primary cultured renal tubular epithelial cells. g mRNA levels and h, i protein levels of MFN2, FIS1, OPA1, RTN3, and β-actin in HEK293 cells transfected with si-Control and si-RTN3.

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