Fig. 3: GC administration elicits an increase in classical monocytes in vivo.
From: Glucocorticoid-induced expansion of classical monocytes contributes to bone loss
a Flow cytometric analysis and the relative proportions of two major monocyte subsets in bone marrow, spleen, and popliteal lymph nodes during GC-induced bone loss in rats (n = 3–6). The relative proportions of classical monocytes (CD43LoHis48Hi) and nonclassical monocytes (CD43HiHis48Lo-Int) are shown (b–g). Monocyte-related cytokines, including MIP-1α, MCP-1, MCP-3, IP-10, and Rantes, and proinflammatory cytokines, including TNFα, IL-6, IFNγ, and IL-1α, in bone marrow (h) and serum (i) samples from the control group and the MP groups (1–5 weeks) are presented (n = 3 per group).
