Fig. 1: The lncRNA TMPO-AS1 (TAS1) is upregulated in ESCC and indicates poor prognosis. | Experimental & Molecular Medicine

Fig. 1: The lncRNA TMPO-AS1 (TAS1) is upregulated in ESCC and indicates poor prognosis.

From: LncRNA TMPO-AS1 promotes esophageal squamous cell carcinoma progression by forming biomolecular condensates with FUS and p300 to regulate TMPO transcription

Fig. 1

a Schematic showing the design of the screen for lncRNAs potentially involved in both cell viability and migration in ESCA. b Eight lncRNAs regulated both cell proliferation and migration in KYSE150 and TE-11 cells, including TAS1; n = 3 biologically independent samples. The p values for each group are shown in Supplementary Table 4. c TAS1 expression in ESCA tissues from TCGA data. d, e TAS1 expression and OS analysis in ESCC samples from the SYSUCC cohort. (n = 108, survival analysis: log-rank test, two-sided). f Detection of TAS1 subcellular localization in KYSE150 cells by FISH. Scale bar: 5 μm. g TAS1 expression in the nuclear and cytoplasmic fractions of KYSE150 cells and TE-11 cells, as detected using qPCR. h Determination of the TAS1 copy number in ESCC cell lines and normal esophageal epithelial cell lines; n = 3, compared with NE1. The data are presented as the mean ± S.D. values. *P < 0.05; **P < 0.01; ***P < 0.001; ns, not significant.

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