Fig. 6: AgomiR-1224-5p accelerates the regeneration of bone defects. | Experimental & Molecular Medicine

Fig. 6: AgomiR-1224-5p accelerates the regeneration of bone defects.

From: MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2

Fig. 6

a Micro-CT reconstruction of representative femoral defects. b H&E-stained section of femoral defects. c Bone density and histomorphological analysis of new bone in the femoral cortical space. d Representative TRAP staining of new bone in the femoral defect. Scale bar, 50 µm. e Quantitative analysis of representative pictures of ADCY2 tissue immunohistochemical staining. f MicroCT reconstruction of skull defect. The round red dotted frame represents the size of the original bone defect model. Scale bar, 1 mm. g H&E-stained sections of skull defects. Scale bar, 200 µm. h Bone density and histomorphological analysis of new bone in the femoral cortical space. The results are presented as the mean ± standard deviation, N = 5; #P ≥ 0.05; *P < 0.05, **P < 0.01; ***P < 0.001 by analysis of variance (ANOVA) with Tukey’s post-hoc test. Scale bar, 500 µm.

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