Table 1 Characteristics of the experimental animals at the end of the study.
Group | Control | STZ | STZ + KF-1607 | STZ + Losartan |
---|---|---|---|---|
Body weight (g) | 509 ± 11 | 226 ± 8* | 236 ± 9* | 240 ± 8* |
Kidney weight (g) | 1.6 ± 0.1 | 1.4 ± 0.1 | 1.6 ± 0.1 | 1.4 ± 0.1 |
Kidney to body weight ratio (%) | 0.3 ± 0.01 | 0.6 ± 0.01* | 0.7 ± 0.03* | 0.5 ± 0.03* |
24-h urine volume (ml) | 18 ± 0.4 | 103 ± 11.3* | 94 ± 11.2* | 84 ± 13.4* |
HbA1C (%) | 3.5 ± 0.1 | 7.0 ± 0.2* | 6.9 ± 0.2* | 7.2 ± 0.2* |
Blood glucose (mg/dl) | 153 ± 5 | 422 ± 39* | 388 ± 17* | 387 ± 3* |
Serum FFA (mM) | 0.24 ± 0.09 | 2.47 ± 0.78* | 2.22 ± 0.49* | 2.01 ± 0.28* |