Table 1 Characteristics of the experimental animals at the end of the study.

From: Pan-Src kinase inhibitor treatment attenuates diabetic kidney injury via inhibition of Fyn kinase-mediated endoplasmic reticulum stress

Group

Control

STZ

STZ + KF-1607

STZ + Losartan

Body weight (g)

509 ± 11

226 ± 8*

236 ± 9*

240 ± 8*

Kidney weight (g)

1.6 ± 0.1

1.4 ± 0.1

1.6 ± 0.1

1.4 ± 0.1

Kidney to body weight ratio (%)

0.3 ± 0.01

0.6 ± 0.01*

0.7 ± 0.03*

0.5 ± 0.03*

24-h urine volume (ml)

18 ± 0.4

103 ± 11.3*

94 ± 11.2*

84 ± 13.4*

HbA1C (%)

3.5 ± 0.1

7.0 ± 0.2*

6.9 ± 0.2*

7.2 ± 0.2*

Blood glucose (mg/dl)

153 ± 5

422 ± 39*

388 ± 17*

387 ± 3*

Serum FFA (mM)

0.24 ± 0.09

2.47 ± 0.78*

2.22 ± 0.49*

2.01 ± 0.28*

  1. The data are presented as the mean ± SE of five rats/group.
  2. *p < 0.05 vs. control.