Fig. 6: PLD2 interacts with c-Fms and PI3K. | Experimental & Molecular Medicine

Fig. 6: PLD2 interacts with c-Fms and PI3K.

From: Phospholipase D2 controls bone homeostasis by modulating M-CSF-dependent osteoclastic cell migration and microtubule stability

Fig. 6

a Endogenous PLD2 in BMMs was immunoprecipitated and subjected to immunoblotting with the indicated antibodies. Nonspecific proteins were immunoprecipitated using normal mouse IgG. b Cytokine-starved BMMs were stimulated with M-CSF (50 ng/ml) for 5 and 15 min and subjected to immunoprecipitation using anti-PLD2 antibody, followed by immunoblotting for the indicated antibodies. TCL, total-cell lysate. c Working model of PLD2 as a negative regulator of osteoclastic bone resorption.

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