Fig. 5: The combined platform with hiPSC-ECs and SDF-eMSC-PA improves cardiac contractibility.

a Representative images of the hemodynamic pressure and volume (PV) curve at steady state at 8 weeks post-cell treatment. b Stroke volume (SV). c Cardiac output (CO). d Volume max (V max) defining the amount of blood volume in the LV at end-diastole. e dP/dtmax refers to the maximal rate of pressure changes during systole. f The minimal rate of pressure changes during diastole (dP/dtmin). g Slope of end-systolic pressure volume relationship (ESPVR) indicating the intrinsic cardiac contractibility as measured by transient inferior vena cava (IVC) occlusion. h Slope of end-diastolic pressure volume relationship (EDPVR). n = 4. *p < 0.05.