Fig. 7: Schematic illustration showing the possible mechanisms by which OGT modulates FAM134B-mediated ER-phagy and promotes cell survival. | Experimental & Molecular Medicine

Fig. 7: Schematic illustration showing the possible mechanisms by which OGT modulates FAM134B-mediated ER-phagy and promotes cell survival.

From: O-GlcNAc transferase regulates intervertebral disc degeneration by targeting FAM134B-mediated ER-phagy

Fig. 7

Under ND conditions, FAM134B is possibly O-GlcNAcylated by OGT, which suppresses its ubiquitination-mediated degradation. Subsequently, enhanced FAM134B-mediated ER-phagy restores intracellular homeostasis and facilitates cell survival.

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