Fig. 9: The role of edAZIN1 in prostate cancer. | Experimental & Molecular Medicine

Fig. 9: The role of edAZIN1 in prostate cancer.

From: AZIN1 RNA editing alters protein interactions, leading to nuclear translocation and worse outcomes in prostate cancer

Fig. 9

The oncoprotein AZIN1 stimulates cell proliferation (wild type AZIN1) (gray arrow). However, ADAR-mediated adenosine-to-inosine (A → I (in red)) editing of AZIN1 transcripts results in a serine (Ser) to glycine (Gly) substitution at residue 367. The RNA edited AZIN1 binds to Myosin 9, Actin gamma 1 and Anti-alpha smooth muscle Actin. Editing also causes nuclear localization of AZIN1, leads to more aggressive cell behavior (increased proliferation, invasion, and soft agar colony formation), and predicts worse prostate cancer outcome.

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