Fig. 8: Schematic diagram showing citratemt accumulation-mediated necroptosis in AECs. | Experimental & Molecular Medicine

Fig. 8: Schematic diagram showing citratemt accumulation-mediated necroptosis in AECs.

From: Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury

Fig. 8

LPS downregulates Idh3α and Slc25a1, leading to citratemt accumulation in AECs. Citratemt accumulation induces DRP1-mediated mitochondrial fission and excessive mitophagy via FUNDC1, which damages mitochondria in AECs. As a consequence of RIPK3 activation, MLKL is phosphorylated and activated, which leads to AEC necroptosis and ALI/ARDS.

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