Fig. 3: Differential gene expression related to the inflammatory response by injection of α-synuclein. | Experimental & Molecular Medicine

Fig. 3: Differential gene expression related to the inflammatory response by injection of α-synuclein.

From: Inflammation promotes synucleinopathy propagation

Fig. 3

a Heatmap representing the expression levels (log2 read count number) of DEGs upregulated (fold change >1.5) or downregulated (fold change <0.5) after injection of WT-syn fibrils or V40G multimers vs. PBS (n = 3 per group). b Venn diagram of DEGs. c, d Simplified networks of significantly enriched GO terms. The network was made from DEGs in WT-Syn-injected mice (c) and V40G-injected mice (d). Each term is statistically significant (Benjamini‒Hochberg correction <0.05). The nodes (colored circles) represent significantly enriched parent GO terms. The edges (lines between the nodes) show that there are overlapping genes within terms. The different sizes of the nodes represent the number of enriched genes. e The top 11 enriched GO terms for the 110 common DEGs in both WT-syn- and V40G-injected mice. f GO enrichment analysis of immune-related common DEGs in both WT-syn- and V40G-injected mice. g Heatmap of the log2 fold changes of 40 common DEGs related to immune and inflammatory responses.

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