Fig. 3: High UBE2C expression promotes the invasion and metastasis of lung adenocarcinoma cells. | Experimental & Molecular Medicine

Fig. 3: High UBE2C expression promotes the invasion and metastasis of lung adenocarcinoma cells.

From: Delineating the dynamic evolution from preneoplasia to invasive lung adenocarcinoma by integrating single-cell RNA sequencing and spatial transcriptomics

Fig. 3

a Bulk RNA-seq analysis (60 cases) validated that the expression level of the UBE2C gene increased in the process of cancer invasion. b Kaplan‒Meier analysis (data for 402 LUAD cases from the TCGA database) revealed that patients with high UBE2C expression had worse progression-free survival (upper panel, P = 0.025) and OS (lower panel, P = 0.0013). c A Transwell assay confirmed that knockdown of the UBE2C gene in the PC-9 LUAD cell line decreased cancer cell migration (upper panel) and invasion (lower panel). d Cell index assay showing that sh-UBE2C inhibits the proliferation of PC-9 lung cancer cells. e Growth curves of xenograft tumors in each group. f Subcutaneous tumor size of each group. g HE representative images of nude mouse xenografts UBE2C and sh-UBE2C.

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