Fig. 2: Cellular and molecular functions of N6-methyladenosine (m6A).
From: Biological roles of the RNA m6A modification and its implications in cancer
a The m6A modification occurs cotranscriptionally via an m6A methyltransferase complex (an m6A writer). b ALKBH5 and FTO dynamically demethylate N6 adenosine in target RNAs. m6A readers (YTHDC1-2, YTHDF1-3, IGF2BP1-3, HNRNPC/G, and HNRNPA2B1) determine the fate of m6A-modified RNAs. c YTHDC1, a nuclear m6A reader, interacts with SRSF3/10 and regulates alternative splicing. d YTHDC1 also controls nuclear export mediated through SRSF3 and NXF1. e YTHDC2, YTHDF1, and YTHDF3 are involved in mRNA stabilization and translation. f YTHDF2 interacts with the mRNA decay machinery and the CCR4-NOT complex, leading to mRNA degradation. g IGF2BP1-3 regulate the stabilization and translation of mRNAs. h HNRNPC and HNRNPG modulate pre-mRNA processing. i HNRNPA2B1 recruits DROSHA-DGCR8 to pri-miRNA for miRNA processing. This image was created with BioRender (https://biorender.com/).
