Fig. 4: Telomere shortening-driven genomic instability by N6-methyladenosine (m6A) and tumorigenesis.
From: Biological roles of the RNA m6A modification and its implications in cancer
a N6-methyladenosine (m6A) of HMBOX1 mRNA induces YTHDF2-mediated mRNA degradation. b A reduction in HMBOX1 gradually shortens telomeres. c Although shortened telomeres induce a dysfunctional telomere-driven DNA damage response (DDR), derepressed MDM2 inactivates the p53-mediated pathway, which is involved in cell cycle arrest or apoptosis. d Genomic instability mediated through sister chromatid exchange (T-SCE) or an anaphase bridge promotes tumorigenesis and cancer progression. This image was created with BioRender (https://biorender.com/).
