Fig. 3: Circulation mtDNA and protein expression in human serum and liver tissues. | Experimental & Molecular Medicine

Fig. 3: Circulation mtDNA and protein expression in human serum and liver tissues.

From: Site-specific ubiquitination of VDAC1 restricts its oligomerization and mitochondrial DNA release in liver fibrosis

Fig. 3

a Top 10 enriched GO molecular functions in livers from healthy subjects and patients with liver cirrhosis. b Heatmap presenting differentially expressed interferon-stimulated genes (ISGs) between human cirrhotic and normal livers. Representative immunoblots and quantitative histogram of (c) Parkin, (d) VDAC1, (e) p-STING/STING, and (f) p-IRF3/IRF3 in human liver tissues (GAPDH or α-Tubulin was used as the loading control) (n = 7/group). Quantified relative levels of the mtDNA reference genes (g) MT-ND1, (h) MT-ND6, (i) MT-RNR2, and (j) MT-ATP6 normalized to the nuclear reference gene β-2 microglobulin in human serum (n = 12/group). Mean ± SEM, *p < 0.05 and ** p < 0.01 between the indicated groups.

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