Fig. 1: Dysregulation of histone modification during gastric carcinogenesis.
From: Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis
Writer and eraser proteins modify the histone tail by adding or removing modifications such as methylation (Me) or acetylation (Ac). These modifications are recognized by reader proteins, which are found in chromatin remodeling complexes capable of altering chromatin accessibility and allowing the binding of transcription factors to regulate gene expression. In GC, the expression of these proteins is dysregulated, leading to the up- and downregulation of oncogenes and tumor suppressors.
