Fig. 3: Developmental delay of OS differentiation in Vax1AA/AA mice.
From: Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant
a Pictures of mouse eyes (frontal view) with the indicated genotypes are taken at various developmental stages. Arrowheads point to the optic fissures. N, nasal; T, temporal; D, dorsal; V, ventral. b Sagittal sections of mouse embryos were stained with hematoxylin & eosin (H&E). Positions of the sections are indicated by blue plates in the diagram (leftmost column). APC, astrocyte precursor cell; ODH, optic disc head; OF, optic fissure; dOS, dorsal optic stalk; vOS, NR, neural retina; RPE, retinal pigment epithelium; ventral optic stalk; vHT, ventral hypothalamus. Scale bars in the pictures are 100 μm. c The distributions of Pax6 and Pax2 in E14.5 mouse embryonic sections were examined by immunostaining. Boxed areas in top row images of coronal sections are magnified in two bottom rows. d Sagittal sections including the medial OS of E14.5 and E16.5 mouse embryos were stained with antibodies that recognize the corresponding markers. APC, astrocyte precursor cell; ONE, optic neuroepithelium; RPC, retinal progenitor cell.
