Fig. 7: Reduced visual acuity of Vax1AA/AA mice.
From: Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant
a Electrophysiological activities of P45 Vax1+/+ and Vax1AA/AA mouse retinas were examined by ERG (see details in Methods). The amplitudes of scotopic b and photopic c ERG a- and b-waves at the 1.6 log cds/m2 condition are presented. The numbers of mice tested are given in the graphs (4 independent litters). d Light-evoked excitation of cortical neurons in P45 Vax1+/+ and Vax1AA/AA mouse V1 was measured by silicon multielectrode probes after monocular illumination (see details in Methods). Responses of neurons in the monocular zones of the ipsilateral (Ipsi) and contralateral (Contra) visual cortices were recorded. The color-coded heatmap represents the average z scores of spike firing rates. Red indicates an increase, and blue indicates a decrease in firing rates from the baseline. e Mean firing-rate change index of ipsilateral and contralateral V1 neurons in Vax1+/+ and Vax1AA/AA mice. The y-axis values are the mean ± SEM. f Relative occupancy of light and dark chambers by P45 Vax1+/+ (WT), Vax1AA/AA (AA), and Pde6brd1/rd1 (rd1) mice for a 10-min measurement period was determined and shown in a graph. g Escaping responses of the mice, which were given the expanding black circle on top screens to mimic a looming shadow of a predator, were determined and shown in a graph. h To determine the stereoscopic vision of the mice, the relative occupancy of safe and cliff zones by the mice for the 2-min measurement period was determined and is shown in a graph. (i) The accuracy of the mice in turning their heads in the directions where black and white vertical stripes rotate was measured and shown in a graph (head turn). Startling responses of the mice in response to the stimuli were also measured (startling). The numbers of mice tested are given in the graphs in f – h.
